Hydrazine hydrate (1:1) → HCID 58190553, compound

HRID 1892411Notes

Reaction equation

HRID 1892411 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[CH:12]([CH3:17])[C:13](OC)=[O:14].O.[NH2:19][NH2:20]>CO>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[CH:12]([CH3:17])[C:13]([NH:19][NH2:20])=[O:14]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58190470HCID 58190470, compound

Product 1

HCID 58190553HCID 58190553, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2-(7-fluoroquinolin-6-yl)propanoate (756 mg, 3.24 mmol) and hydrazine monohydrate (1.5 mL) in methanol (5 mL) was heated at 50° C. overnight. After cooling, the solvent was removed in vacuo to afford the title compound (756 mg, 100%) which was used without further purification. LCMS (method A): [MH]+=234, tR=3.14 min.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-a1c0d57142514d4cabc13bc2ebbb8baf
Source dataset
uspto-grants-2013_08
Patent number
US08507676B2

Reaction notes

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