反应详情

To a suspension of 4-(bromomethyl)-2-fluorobenzoic acid (914.2 mg, 3.923 mmol) in toluene (20 ml) was added triphenylphosphine (1.029 g, 3.923 mmol). After heating the mixture under reflux for 6 hr, the reaction mixture was cooled to room temperature. The precipitate was collected by filtration, and dried under reduced pressure to give (4-carboxy-3-fluorobenzyl)(triphenyl)phosphoniumbromide (2.057 g, quantitative) as a white solid.

1. temperatureAfter heating the mixture
2. temperatureunder reflux for 6 hr
3. filtrationThe precipitate was collected by filtration
4. customdried under reduced pressure