反应详情

To a solution of tert-butyl 2-(4-nitrophenyl)ethyl hydrazine-1,2-dicarboxylate (9.780 g, 30.00 mmol) in ethyl acetate (100 ml) was added 10% palladium carbon (980.0 mg, containing 50% water), and the mixture was hydrogenated at room temperature and atmospheric pressure. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was suspended in a mixture of hexane (70 ml) and ethyl acetate (30 ml), filtered and dried under reduced pressure to give 2-(4-aminophenyl)ethyl tert-butyl hydrazine-1,2-dicarboxylate (5.207 g, 17.63 mmol, yield 58.8%) as a white solid.

1. customwas hydrogenated at room temperature
2. filtrationThe reaction mixture was filtered through celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. additionThe residue was suspended in a mixture of hexane (70 ml) and ethyl acetate (30 ml)
5. filtrationfiltered
6. customdried under reduced pressure