反应详情

N-{3-[2-(4-Hydroxyphenyl)vinyl]-1,3-thiazol-2-yl}acetamide (1.900 g, 7.299 mmol) was dissolved in a mixture of ethyl acetate (300 ml) and acetic acid (50 ml), and 10% palladium carbon (760 mg, containing 50% water) was added. The mixture was hydrogenated at room temperature under 4-5 atm. After the completion of the reaction, the reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate by heating, and recrystallized by cooling to give N-{3-[2-(4-hydroxyphenyl)ethyl]-1,3-thiazol-2-yl}acetamide (1.834 g, 6.993 mmol, yield 95.8%) as a white solid.

1. additionwas added
2. customwas hydrogenated at room temperature under 4-5 atm
3. customAfter the completion of the reaction
4. filtrationthe reaction mixture was filtered through celite
5. concentrationthe filtrate was concentrated under reduced pressure
6. dissolutionThe residue was dissolved in ethyl acetate
7. temperatureby heating
8. customrecrystallized
9. temperatureby cooling