1,4-Dioxane hydrochloride → HCID 86650029, compound

HRID 1892525Notes

Reaction equation

HRID 1892525 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][C:12]2[CH:30]=[CH:29][C:15]([CH2:16][NH:17][C:18]([NH:20][NH:21]C(OC(C)(C)C)=O)=[O:19])=[CH:14][C:13]=2[F:31])[N:9]=1)(=[O:3])[CH3:2].O1CCOCC1.[ClH:38]>O1CCOCC1>[ClH:38].[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][C:12]2[CH:30]=[CH:29][C:15]([CH2:16][NH:17][C:18]([NH:20][NH2:21])=[O:19])=[CH:14][C:13]=2[F:31])[N:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86762011HCID 86762011, compound

Product 1

HCID 86650029HCID 86650029, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 2-[(4-{2-[2-(acetylamino)-1,3-thiazol-4-yl]ethyl}-3-fluorobenzyl)carbamoyl]hydrazinecarboxylate (12.3 mg, 0.027 mmol) in dioxane (1.2 ml) was added 4M hydrogen chloride dioxane solution (0.1 ml), and the mixture was stirred at room temperature for 17 hr, and concentrated under reduced pressure.The residue was suspended in ethyl acetate (2 ml), and the mixture was filtered. The filtered product was washed 3 times with ethyl acetate, and dried under reduced pressure to give the title compound (10.2 mg, 0.026 mmol, yield 96.7%) as a white solid.

Workup

  1. concentrationconcentrated under reduced pressure
  2. filtrationthe mixture was filtered
  3. washThe filtered product was washed 3 times with ethyl acetate
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-eae3c10d673246f3bf48cd485d52dde5
Source dataset
uspto-grants-2013_08
Patent number
US08507690B2

Reaction notes

Loading…