1,4-Dioxane hydrochloride → HCID 86650029, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-[(4-{2-[2-(acetylamino)-1,3-thiazol-4-yl]ethyl}-3-fluorobenzyl)carbamoyl]hydrazinecarboxylate (12.3 mg, 0.027 mmol) in dioxane (1.2 ml) was added 4M hydrogen chloride dioxane solution (0.1 ml), and the mixture was stirred at room temperature for 17 hr, and concentrated under reduced pressure.The residue was suspended in ethyl acetate (2 ml), and the mixture was filtered. The filtered product was washed 3 times with ethyl acetate, and dried under reduced pressure to give the title compound (10.2 mg, 0.026 mmol, yield 96.7%) as a white solid.

Provenance & Evidence