反应详情

To 4-(methoxycarbonyl)picolinic acid (150 g, 1.82 mol) in dichloromethane (500 mL) was added oxalyl chloride (400 mL) keeping the temperature at 25-30° C. for 3 days. The reaction was evaporated in vacuo to afford methyl 2-(chlorocarbonyl)isonicotinate as yellow oil.

1. customat 25-30° C.
2. customfor 3 days
3. customThe reaction was evaporated in vacuo