Glutamic acid diethyl ester → HCID 178471563, compound

HRID 1892629Notes

Reaction equation

[NH2:1][C:2]1[NH:7][C:6]2[NH:8][CH:9]=[C:10]([CH2:11][CH2:12][C:13]3[CH:21]=[CH:20][C:16]([C:17]([OH:19])=O)=[CH:15][CH:14]=3)[C:5]=2[C:4](=[O:22])[N:3]=1.[NH2:23][C@H:24]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28]>>[CH2:35]([O:34][C:32](=[O:33])[C@H:24]([CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])[NH:23][C:17](=[O:19])[C:16]1[CH:20]=[CH:21][C:13]([CH2:12][CH2:11][C:10]2[C:5]3[C:4](=[O:22])[N:3]=[C:2]([NH2:1])[NH:7][C:6]=3[NH:8][CH:9]=2)=[CH:14][CH:15]=1)[CH3:36]

Participants

Reactant 2

HCID 73961Glutamic acid diethyl ester

HCID 178508847HCID 178508847, compound

Product 1

HCID 178471563HCID 178471563, compound

Procedure

condensing 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid with diethyl L-glutamate hydrochlorate to give N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl-L-glutamic acid diethyl ester, and then forming a p-toluenesulfonate salt thereof; and

Sources & evidence

ORD record: ord-cfbbfca6a9624808841080a261d557e6
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507716B2

Reaction notes

Loading…