Ethyl 4-iodobenzoate → Ethyl 4-(cyclobutyl(hydroxy)methyl)benzoate

HRID 1892663Notes

Reaction equation

I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.[CH:13]1([CH:17]=[O:18])[CH2:16][CH2:15][CH2:14]1>>[CH:13]1([CH:17]([OH:18])[C:2]2[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=2)[CH2:16][CH2:15][CH2:14]1

Participants

Reactant 2

HCID 142891Ethyl 4-iodobenzoate

HCID 12431621Cyclobutanecarbaldehyde

Product 1

HCID 68157714Ethyl 4-(cyclobutyl(hydroxy)methyl)benzoate

Procedure

The title compound was prepared by a method analogous to that described for Intermediate (16), using ethyl 4-iodobenzoate and cyclobutanecarbaldehyde. 1H NMR (400 MHz, CDCl3, δ): 7.93 (d, J=8.0 Hz, 2H), 7.31 (d, J=8.0 Hz, 2H), 4.58 (d, J=8.0 Hz, 1H), 4.29 (q, J=6.8 Hz, 2H), 2.50-2.58 (m, 1H), 1.70-2.02 (m, 6H), 1.34 (t, J=7.2 Hz, 3H).

Sources & evidence

ORD record: ord-85da38dc6f9e4adebeef67b4c23df2c2
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507533B2

Reaction notes

Loading…