Oxalyl chloride → 946488-78-4

HRID 1892701Notes

Reaction equation

HRID 1892701 reaction equation
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

Product 1

HCID 83855003946488-78-4Yield 50%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

Workup

  1. concentrationbefore concentrating in vacuo

Sources & evidence

ORD record
ord-f3e720efe64947b29f211079368d7456
Source dataset
uspto-grants-2013_08
Patent number
US08507533B2

Reaction notes

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