Ethyl isocyanate → HCID 60969782, compound

HRID 1892812Notes

Reaction equation

HRID 1892812 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH2:13]([N:15]=[C:16]=[O:17])[CH3:14]>O1CCCC1>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([S:9]([NH2:12])(=[O:11])=[O:10])=[CH:3][C:2]=1[NH:1][C:16]([NH:15][CH2:13][CH3:14])=[O:17]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 957943-Amino-4-chlorobenzenesulphonamide

Product 1

HCID 60969782HCID 60969782, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 3-amino-4-chlorobenzenesulfonamide (420 mg) in tetrahydrofuran (2 ml) solution, ethylisocyanate (180 μl) was added and the mixture was stirred under heating and reflux for 15 hours. The reaction solution was concentrated, then the residue was recrystallized from chloroform/methanol to obtain the title compound as a crude product (550 mg).

Workup

  1. temperatureunder heating
  2. temperaturereflux for 15 hours
  3. concentrationThe reaction solution was concentrated
  4. customthe residue was recrystallized from chloroform/methanol

Sources & evidence

ORD record
ord-00ae80a5dfa4438ea8b5277e1b3f25ac
Source dataset
uspto-grants-2013_08
Patent number
US08507714B2

Reaction notes

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