HRID1892838

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：COC(=O)c1cc(S(=O)(=O)N2CC(=O)NC/C(=C\c3cc(Cl)ccc3OC)C2=O)ccc1Cl$

HCID57670914

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(S(=O)(=O)N2CC(=O)NCC(Cc3ccccc3)C2=O)cc1

HCID57670935

未命名化合物

PROCEDURE

实验过程

4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid, synthesized by using 4-(tert-butoxycarbonyl)benzenesulfonamide instead of the starting material compound of Example 198, that is, 3-(tert-butoxycarbonyl)benzenesulfonamide for the similar procedure as in Example 198, was used instead of the starting material of Example 208, that is, the compound 196, for the similar procedure as with Example 208 to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a53d7dc76644fdba2b200107e769985
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08507714B2
来源说明: uspto-grants-2013_08

反应 SMILES

[CH2:1]([CH:8]1[C:14](=[O:15])[N:13]([S:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:12][C:11](=[O:28])[NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29](OC(C1C=CC(S(N)(=O)=O)=CC=1)=O)(C)(C)C.C(C1C(=O)N(S(C2C=C(C=CC=2)C(O)=O)(=O)=O)CC(=O)NC1)C1C=CC=CC=1.C(OC(C1C=C(S(N)(=O)=O)C=CC=1)=O)(C)(C)C.ClC1C=CC(S(N2C(=O)/C(=C/C3C=C(Cl)C=CC=3OC)/CNC(=O)C2)(=O)=O)=CC=1C(OC)=O>>[CH2:1]([CH:8]1[C:14](=[O:15])[N:13]([S:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23]([O:25][CH3:29])=[O:24])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:12][C:11](=[O:28])[NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1