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methyl 2-chloro-5-{[(6E)-6-(5-chloro-2-methoxybenzylidene)-3,7-dioxo-1,4-diazepan-1-yl]sulfonyl}benzoate → Methyl 4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | methyl 2-chloro-5-{[(6E)-6-(5-chloro-2-methoxybenzylidene)-3,7-dioxo-1,4-diazepan-1-yl]sulfonyl}benzoate | HCID 57670914 | — |
| 反応物 | 3-[(6-Benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid | HCID 57671085 | — |
| 反応物 | 4-(Tert-butoxycarbonyl)benzenesulfonamide | HCID 59733636 | — |
| 反応物 | Tert-butyl 3-sulfamoylbenzoate | HCID 59733695 | — |
| 反応物 | 4-[(6-Benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid | HCID 66934750 | — |
| 生成物 | Methyl 4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoate | HCID 57670935 | — |
反応手順
4-[(6-benzyl-3,7-dioxo-1,4-diazepan-1-yl)sulfonyl]benzoic acid, synthesized by using 4-(tert-butoxycarbonyl)benzenesulfonamide instead of the starting material compound of Example 198, that is, 3-(tert-butoxycarbonyl)benzenesulfonamide for the similar procedure as in Example 198, was used instead of the starting material of Example 208, that is, the compound 196, for the similar procedure as with Example 208 to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08507714B2 |
| 出典データセット | uspto-grants-2013_08 |
| ORD ID | ord-9a53d7dc76644fdba2b200107e769985 |
| 出典メモ | uspto-grants-2013_08 |