反应详情

Compound 4a (14.5 g, 21.7 mmol) was dissolved in ethyl acetate (100 mL) and purged with argon. To the solution was added 10% palladium on carbon (2 g). The flask was purged with hydrogen 2 times and stirred further at room temperature under hydrogen atmosphere for overnight. The disappearance of the starting material was confirmed by the TLC. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate. The combined organic layer was concentrated under reduced pressure to afford compound 5 (10.56 g, 91%) as white solid. This was used as such for the next step.

1. custompurged with argon
2. additionTo the solution was added 10% palladium on carbon (2 g)
3. customThe flask was purged with hydrogen 2 times
4. filtrationThe reaction mixture was filtered through a pad of Celite
5. washwashed with ethyl acetate
6. concentrationThe combined organic layer was concentrated under reduced pressure