Water → 1,8-Nonadiyne

HRID 1893085Notes

Reaction equation

HRID 1893085 reaction equation
C[C@@H]1[O:7][C@@H](O[C@@H:9]2[C:14]3=C(O)[C:16]4C(=O)C5C(=CC=CC=5OC)C(=O)[C:17]=4[C:18](O)=[C:13]3[CH2:12][C@@:11](O)(C(CO)=O)[CH2:10]2)C[C@H](N)[C@@H]1O.Cl.C[C@@H]1O[C@@H](O[C@@H]2C3=C(O)C4C(=O)C5C(=CC=CC=5OC)C(=O)C=4[C:58]([OH:59])=[C:53]3[CH2:52][C@@:51]([OH:77])([C:73]([CH2:75][OH:76])=[O:74])C2)C[C@H](N)[C@@H]1O.C#CCCCCCC#C.[OH2:89]>CS(C)=O>[CH:14]#[C:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:18][C:17]#[CH:16].[O:89]=[C:75]1[O:76][C@H:52]([C@H:53]([CH2:58][OH:59])[OH:7])[C:51]([OH:77])=[C:73]1[OH:74]

Participants

7

Reactant 4

HCID 962Water3×HCID 169691,8-NonadiyneHCID 31703DoxorubicinHCID 443939Doxorubicin Hydrochloride

Product 2

HCID 169691,8-NonadiyneHCID 54670067L-Ascorbic Acid

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

100 mg of product 1 are dissolved in 1.1 ml of distilled water; a solution of 200 μl of 1,8-Nonadiyne in 11.23 ml of DMSO are prepared separately, whereas 23.2 mg of doxorubicin hydrochloride are dissolved in 0.5 ml of distilled water. The solution of hyaluronic acid is mixed with that of doxorubicin and with 0.2 ml of that of 1,8-Nonadiyne; 0.1 ml of an aqueous solution obtained with 50 mg of CuSO4.5H2O in 1 ml of H2O and 0.1 ml of an aqueous solution of 20 mg of ascorbic acid are then added. The mixture is stirred vortically for a few minutes. The rapidly formed gel (see FIG. 31) incorporates the doxorubicin hydrochloride inside.

Sources & evidence

ORD record
ord-e5bd4892c1d84109845d13b3189e1e58
Source dataset
uspto-grants-2013_08
Patent number
US08512752B2

Reaction notes

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