HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyl triflate → Acetic acid 2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyl triflate | HCID 65367 | — |
| Reactant | 6-Benzamidopurine | HCID 97075 | — |
| Reactant | Acetic acid 3-acetoxy-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl ester | HCID 131730809 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Acetic acid 2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl ester | HCID 131730810 | 68% |
Reaction Steps
A flask was charged with Acetic acid 3-acetoxy-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl ester, acetonitrile, the trimethylsilyl triflate (TMSOTf). To the reaction was added N6-benzoyl adenine. The reaction was stirred, extracted, and the solvent was evaporated to provide the titled compound in 68% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513214B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-63c85fc8b1304f72be5ba0cfdc247b07 |
| Source note | uspto-grants-2013_08 |