HRID1893159

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID65367

Methanesulfonic acid, trifluoro-, trimethylsilyl ester

C4H9F3O3SSi

HCID97075

Benzamide, N-1H-purin-6-yl-

C12H9N5O

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(OC(C)=O)C(OC(C)=O)C1OCc1ccccc1

HCID131730809

未命名化合物

PRODUCTS

生成物

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(NC(=O)c4ccccc4)ncnc32)C(OC(C)=O)C1OCc1ccccc1

HCID131730810

未命名化合物

收率 68%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A flask was charged with Acetic acid 3-acetoxy-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl ester, acetonitrile, the trimethylsilyl triflate (TMSOTf). To the reaction was added N6-benzoyl adenine. The reaction was stirred, extracted, and the solvent was evaporated to provide the titled compound in 68% yield.

WORKUP

后处理

extractionextracted
customthe solvent was evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-63c85fc8b1304f72be5ba0cfdc247b07
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513214B2
来源说明: uspto-grants-2013_08

反应 SMILES

[C:1]([O:4][CH:5]1[CH:9]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([C:20]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:21][SiH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])([CH:18]=[CH2:19])[O:7][CH:6]1OC(=O)C)(=[O:3])[CH3:2].O([Si](C)(C)C)S(C(F)(F)F)(=O)=O.[C:55]([NH:63][C:64]1[N:72]=[CH:71][N:70]=[C:69]2[C:65]=1[NH:66][CH:67]=[N:68]2)(=[O:62])[C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1>C(#N)C>[C:55]([NH:63][C:64]1[N:72]=[CH:71][N:70]=[C:69]2[C:65]=1[N:66]=[CH:67][N:68]2[CH:6]1[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH:9]([O:10][CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:8]([C:20]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[O:21][SiH2:22][C:23]([CH3:24])([CH3:25])[CH3:26])([CH:18]=[CH2:19])[O:7]1)(=[O:62])[C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1