HRID1893160

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(NC(=O)c4ccccc4)ncnc32)C(OC(C)=O)C1OCc1ccccc1

HCID131730810

未命名化合物

PRODUCTS

生成物

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(N)ncnc32)C(O)C1OCc1ccccc1

HCID131730811

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a flask charged with Acetic acid 2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl ester was added methanol and NH3. The reaction was stirred, extracted, and the solvent was evaporated to provide the titled compound in 96% yield.

WORKUP

后处理

extractionextracted
customthe solvent was evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0fcfa46411944c1aa8aa1f5c4b0a8c85
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513214B2
来源说明: uspto-grants-2013_08

反应 SMILES

C([NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[CH:19]1[CH:23]([O:24]C(=O)C)[CH:22]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:21]([C:38]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[O:39][SiH2:40][C:41]([CH3:44])([CH3:43])[CH3:42])([CH:36]=[CH2:37])[O:20]1)(=O)C1C=CC=CC=1.N>CO>[NH2:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[CH:19]1[CH:23]([OH:24])[CH:22]([O:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:21]([C:38]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)([C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)[O:39][SiH2:40][C:41]([CH3:42])([CH3:43])[CH3:44])([CH:36]=[CH2:37])[O:20]1