HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(6-Amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Acetic acid 2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl ester | HCID 131730810 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(6-Amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-ol | HCID 131730811 | 96% |
Reaction Steps
To a flask charged with Acetic acid 2-(6-benzoylamino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl ester was added methanol and NH3. The reaction was stirred, extracted, and the solvent was evaporated to provide the titled compound in 96% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513214B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-0fcfa46411944c1aa8aa1f5c4b0a8c85 |
| Source note | uspto-grants-2013_08 |