HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylstannane → 9-[4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl]-9H-purin-6-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylstannane | HCID 5948 | — |
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | Thiocarbonic acid O-[2-(6-amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl]ester O-phenyl ester | HCID 131730812 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 9-[4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-2-yl]-9H-purin-6-ylamine | HCID 131730813 | 90% |
Reaction Steps
To a flask was added Thiocarbonic acid O-[2-(6-amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl]ester O-phenyl ester, toluene, tributyl tin hydride, and AIBN. The reaction was stirred at reflux, cooled back to room temperature, was extracted, and the solvent was removed to provide the titled compound in 90% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513214B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-a8bbdec765a84e888e9771077e2ecb70 |
| Source note | uspto-grants-2013_08 |