HRID1893162

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5948

Tributylstannane

C12H28Sn

HCID6547

Azobisisobutyronitrile

C8H12N4

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(N)ncnc32)C(OC(=S)Oc2ccccc2)C1OCc1ccccc1

HCID131730812

未命名化合物

PRODUCTS

生成物

结构：C=CC1(C(O[SiH2]C(C)(C)C)(c2ccccc2)c2ccccc2)OC(n2cnc3c(N)ncnc32)CC1OCc1ccccc1

HCID131730813

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

To a flask was added Thiocarbonic acid O-[2-(6-amino-purin-9-yl)-4-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-vinyl-tetrahydro-furan-3-yl]ester O-phenyl ester, toluene, tributyl tin hydride, and AIBN. The reaction was stirred at reflux, cooled back to room temperature, was extracted, and the solvent was removed to provide the titled compound in 90% yield.

WORKUP

后处理

temperatureat reflux
extractionwas extracted
customthe solvent was removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8bbdec765a84e888e9771077e2ecb70
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513214B2
来源说明: uspto-grants-2013_08

反应 SMILES

C1(OC(=S)O[CH:10]2[CH:14]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:13]([C:25]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[O:26][SiH2:27][C:28]([CH3:31])([CH3:30])[CH3:29])([CH:23]=[CH2:24])[O:12][CH:11]2[N:44]2[CH:52]=[N:51][C:50]3[C:45]2=[N:46][CH:47]=[N:48][C:49]=3[NH2:53])C=CC=CC=1.C([SnH](CCCC)CCCC)CCC.CC(N=NC(C#N)(C)C)(C#N)C>C1(C)C=CC=CC=1>[CH2:16]([O:15][CH:14]1[C:13]([C:25]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[O:26][SiH2:27][C:28]([CH3:31])([CH3:30])[CH3:29])([CH:23]=[CH2:24])[O:12][CH:11]([N:44]2[CH:52]=[N:51][C:50]3[C:45]2=[N:46][CH:47]=[N:48][C:49]=3[NH2:53])[CH2:10]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1