HCID 12134925, compound → Ethyl 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionate

HRID 1893172Notes

Reaction equation

HRID 1893172 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[C:5]([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:29])[C:5]([CH3:21])([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 12134925HCID 12134925, compound

Product 1

HCID 11220314Ethyl 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionateYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Phenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester (24.1 g, 59.3 mmol) was dissolved in ethanol (200 mL) and treated with 10% palladium on carbon (2.41 g), and then stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to produce 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester colorless oil (16.9 g, 95%).

Workup

  1. filtrationThe suspension was filtered through celite and
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f80224c15f1f4ef7ad3c688c9e6f14b6
Source dataset
uspto-grants-2013_08
Patent number
US08513233B2

Reaction notes

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