Piperazine → HCID 59493240, compound

HRID 1893175Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:30])[C:5]([CH3:29])([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18](Cl)[N:17]=[C:16]([NH2:21])[N:15]=2)=[CH:9][CH:8]=1)[CH3:2].[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH2:1]([O:3][C:4](=[O:30])[C:5]([CH3:29])([O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([N:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)[N:17]=[C:16]([NH2:21])[N:15]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

Reactant 2

HCID 4837Piperazine

HCID 86645620HCID 86645620, compound

Product 1

HCID 59493240HCID 59493240, compound

Procedure

3-[4-(2-Amino-6-chloro-pyrimidin-4-yloxy)-phenyl]-2-methyl-2-phenoxy-propionic acid ethyl ester and piperazine were reacted, as described in Example 2, Step G, to provide 3-[4-(2-Amino-6-piperazin-1-yl-pyrimidin-4-yloxy)-phenyl]-2-methyl-2-phenoxy-propionic acid ethyl ester, shown below, as a yellow oil.

Sources & evidence

ORD record: ord-6c3c7b5a76914c9195a04369323c1254
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513233B2

Reaction notes

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