Trifluoroacetic acid → 1-(4-benzo[1,3]dioxol-5-yl-cyclohex-3-enyl)-azetidin-3-ylamine TFA salt

HRID 1893219Notes

Reaction equation

HRID 1893219 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:11][N:10]([CH:12]2[CH2:17][CH2:16][C:15]([C:18]3[CH:26]=[CH:25][C:21]4[O:22][CH2:23][O:24][C:20]=4[CH:19]=3)=[CH:14][CH2:13]2)[CH2:9]1)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[OH:34][C:28]([C:30]([F:33])([F:32])[F:31])=[O:29].[O:22]1[C:21]2[CH:25]=[CH:26][C:18]([C:15]3[CH2:16][CH2:17][CH:12]([N:10]4[CH2:11][CH:8]([NH2:7])[CH2:9]4)[CH2:13][CH:14]=3)=[CH:19][C:20]=2[O:24][CH2:23]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59541968[1-(4-Benzo[1,3]dioxol-5-yl-cyclohex-3-enyl)-azetidin-3-yl]-carbamic acid tert-butyl ester

Product 1

HCID 866466771-(4-benzo[1,3]dioxol-5-yl-cyclohex-3-enyl)-azetidin-3-ylamine TFA salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [1-(4-Benzo[1,3]dioxol-5-yl-cyclohex-3-enyl)-azetidin-3-yl]-carbamic acid tert-butyl ester (as prepared in the previous step, 750 mg, 2.02 mmol) in DCM (5 mL) and TFA (5 mL) was stirred at room temperature for 2 hours. The solvent was removed under vacuum to give the title compound as colorless oil.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-8fa9478c3c3a470abc3741ae28df2204
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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