Dimethylformamide → 1-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

HRID 189322Notes

Reaction equation

HRID 189322 reaction equation
[CH3:36][N:37]([CH3:38])[CH:39]=[O:40].[Cl:33][CH2:34][Cl:35].[N:18](=[C:19]=[O:20])[c:21]1[c:22]([O:31][CH3:32])[cH:23][cH:24][c:25]([C:27]([F:28])([F:29])[F:30])[cH:26]1.[n:1]1[cH:2][cH:3][c:4]([CH2:7][n:8]2[cH:9][n:10][c:11]3[c:12]2[cH:13][cH:14][cH:15][c:16]3[NH2:17])[cH:5][cH:6]1>>[n:1]1[cH:2][cH:3][c:4]([CH2:7][n:8]2[cH:9][n:10][c:11]3[c:12]2[cH:13][cH:14][cH:15][c:16]3[NH:17][C:19]([NH:18][c:21]2[c:22]([O:31][CH3:32])[cH:23][cH:24][c:25]([C:27]([F:28])([F:29])[F:30])[cH:26]2)=[O:20])[cH:5][cH:6]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 11983909Benzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)-HCID 594286291-(Pyridin-4-yl)methyl-1H-benzimidazol-4-ylamine

Product 1

HCID 498059681-(2-Methoxy-5-trifluoromethyl-phenyl)-3-(1-pyridin-4-ylmethyl-1H-benzoimidazol-4-yl)-urea

Sources & evidence

ORD record
ord-a94d269d12674f839ce8a778ecdc89e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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