1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 49763570, compound

HRID 1893223Notes

Reaction equation

HRID 1893223 reaction equation
CCN=C=NCCCN(C)C.[O:12]1[C:16]2[CH:17]=[C:18]([C:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:30][CH:29]([NH2:31])[CH2:28]4)[CH2:23][CH:22]=3)[CH:19]=[CH:20][C:15]=2[CH2:14][CH2:13]1.[F:32][C:33]([F:48])([F:47])[C:34]1[CH:35]=[C:36]([CH:44]=[CH:45][CH:46]=1)[C:37]([NH:39][CH2:40][C:41](O)=[O:42])=[O:38]>>[O:12]1[C:16]2[CH:17]=[C:18]([CH:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:30][CH:29]([NH:31][C:41]([CH2:40][NH:39][C:37](=[O:38])[C:36]5[CH:44]=[CH:45][CH:46]=[C:34]([C:33]([F:48])([F:32])[F:47])[CH:35]=5)=[O:42])[CH2:28]4)[CH2:23][CH2:22]3)[CH:19]=[CH:20][C:15]=2[CH2:14][CH2:13]1

Participants

4

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 2777432((3-(Trifluoromethyl)benzoyl)amino)acetic acidHCID 59541899HCID 59541899, compound

Product 1

HCID 49763570HCID 49763570, compound

Procedure

The title compounds were prepared as white solids from the EDCI coupling between the amine (from step D) and (3-trifluoromethyl-benzoylamino)-acetic acid followed by H-Cube hydrogenation using the procedures described in Steps E and F of Example 1.

Sources & evidence

ORD record
ord-f17ff3f610ce43c0acd552c6228290a2
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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