HCID 15023907, compound → HCID 49764574, compound

HRID 1893269Notes

Reaction equation

HRID 1893269 reaction equation
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2([OH:17])[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[NH:19]1[CH2:22][CH:21]([NH:23][C:24]([CH2:26][NH:27][C:28](=[O:39])[C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)=[O:25])[CH2:20]1>>[OH:17][C:10]1([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:2])=[O:18])=[CH:5][CH:6]=2)[CH2:15][CH2:14][CH:13]([N:19]2[CH2:22][CH:21]([NH:23][C:24](=[O:25])[CH2:26][NH:27][C:28](=[O:39])[C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:37])([F:38])[F:36])[CH:30]=3)[CH2:20]2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 15023907HCID 15023907, compoundHCID 59361594N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide

Product 1

HCID 49764574HCID 49764574, compound

Procedure

The title compound was prepared as a white solid by reductive amination of 4-(1-hydroxy-4-oxo-cyclohexyl)-benzoic acid methyl ester (as prepared in Example 9, Step B) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in step B of Example 4) using the procedure described in Step C of Example 4 followed by base catalyzed hydrolysis of the ester using the procedure described in Example 10.

Sources & evidence

ORD record
ord-88427252e5284ce2a406bb6866033156
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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