1-Bromo-4-fluorobenzene → 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1893272Notes

Reaction equation

HRID 1893272 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][CH:3]=1.[O:9]1[C:13]2([CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]2)[O:12][CH2:11][CH2:10]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:16]2([OH:19])[CH2:17][CH2:18][C:13]3([O:12][CH2:11][CH2:10][O:9]3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 152326818-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from 4-fluoro-phenyl-bromide (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-db25528189d84fd0bb8a4bfc41f28a34
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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