4-Bromobenzamide → 4-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-benzamide

HRID 1893281Notes

Reaction equation

Br[C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1>>[OH:21][C:18]1([C:2]2[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=2)[CH2:19][CH2:20][C:15]2([O:11][CH2:12][CH2:13][O:14]2)[CH2:16][CH2:17]1

Participants

Reactant 2

HCID 696834-Bromobenzamide

HCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 595419794-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-benzamide

Procedure

The title compound was prepared as a white solid from 4-bromobenzamide (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record: ord-ae53260f4b644e8e86dc7c2b577e503c
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513229B2

Reaction notes

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