4-Bromo-2-fluoroanisole → 8-(3-Fluoro-4-methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

HRID 1893284Notes

Reaction equation

HRID 1893284 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([F:10])[CH:3]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[O:21])[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1>>[F:10][C:4]1[CH:3]=[C:2]([C:18]2([OH:21])[CH2:19][CH2:20][C:15]3([O:14][CH2:13][CH2:12][O:11]3)[CH2:16][CH2:17]2)[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

Participants

3

Reactant 2

HCID 753784-Bromo-2-fluoroanisoleHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 595419628-(3-Fluoro-4-methoxyphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

Procedure

The title compound was prepared as a white solid from 4-bromo-2-fluoro-anisole (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-7ebcbfad7cc344d9acf9d0a062889035
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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