Hydrochloric Acid → HCID 49764955, compound

HRID 1893286Notes

Reaction equation

HRID 1893286 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2([OH:41])[CH2:19][CH2:18][CH:17]([N:20]3[CH2:23][CH:22]([NH:24][C:25](=[O:40])[CH2:26][NH:27][C:28](=[O:39])[C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=4)[CH2:21]3)[CH2:16][CH2:15]2)[CH:9]=1)(C)(C)C.Cl>C(Cl)Cl>[NH2:7][C:8]1[CH:9]=[C:10]([C:14]2([OH:41])[CH2:15][CH2:16][CH:17]([N:20]3[CH2:23][CH:22]([NH:24][C:25]([CH2:26][NH:27][C:28](=[O:39])[C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:36])[F:37])[CH:30]=4)=[O:40])[CH2:21]3)[CH2:18][CH2:19]2)[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 49764703HCID 49764703, compound

Product 1

HCID 49764955HCID 49764955, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [3-(1-Hydroxy-4-{3-[2-(3-trifluoromethyl-benzoylamino)-acetylamino]-azetidin-1-yl}-cyclohexyl)-phenyl]-carbamic acid tert-butyl ester (as prepared in the previous step, 25 mg) in DCM (1 mL) was added 4N HCl (200 μL). The reaction was stirred at RT and concentrated in vacuo resulting in the title compound.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ac09917ca7dc493981d9f986fc04d11a
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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