5-bromo-3-methyl-3H-benzooxazol-2-one → 5-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-3-methyl-3H-benzooxazol-2-one

HRID 1893293Notes

Reaction equation

HRID 1893293 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[N:7]([CH3:11])[C:6]=2[CH:12]=1.[O:13]1[C:17]2([CH2:22][CH2:21][C:20](=[O:23])[CH2:19][CH2:18]2)[O:16][CH2:15][CH2:14]1>>[OH:23][C:20]1([C:2]2[CH:3]=[CH:4][C:5]3[O:9][C:8](=[O:10])[N:7]([CH3:11])[C:6]=3[CH:12]=2)[CH2:21][CH2:22][C:17]2([O:13][CH2:14][CH2:15][O:16]2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 3374695-bromo-3-methyl-3H-benzooxazol-2-oneHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 595419875-(8-Hydroxy-1,4-dioxa-spiro[4.5]dec-8-yl)-3-methyl-3H-benzooxazol-2-one

Procedure

The title compound was prepared as a white solid from 5-bromo-3-methyl-3H-benzooxazol-2-one (prepared by methylation of 5-bromo-3H-benzooxazol-2-one from Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-4990443ea434419899e8a3922e822692
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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