HRID1893307

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31268

Pyrrolidine

C4H9N

结构：O=C(CNC(=O)c1cc(C(F)(F)F)ccc1F)NC1CN(C2CCC(c3ccccc3)CC2)C1

HCID49763099

未命名化合物

PRODUCTS

生成物

结构：O=C(CNC(=O)c1cc(C(F)(F)F)ccc1N1CCCC1)NC1CN(C2CCC(c3ccccc3)CC2)C1

HCID49763226

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as a white solid from coupling of 2-fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide (as prepared in Example 66) and pyrrolidine (Aldrich) using the procedure described in Example 69.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b47ea647184b4e04a12cc2d69f538262
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08513229B2
来源说明: uspto-grants-2013_08

反应 SMILES

F[C:2]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:3]=1[C:4]([NH:6][CH2:7][C:8](=[O:26])[NH:9][CH:10]1[CH2:13][N:12]([CH:14]2[CH2:19][CH2:18][CH:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)[CH2:11]1)=[O:5].[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[C:20]1([CH:17]2[CH2:16][CH2:15][CH:14]([N:12]3[CH2:11][CH:10]([NH:9][C:8]([CH2:7][NH:6][C:4](=[O:5])[C:3]4[CH:27]=[C:28]([C:31]([F:33])([F:34])[F:32])[CH:29]=[CH:30][C:2]=4[N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[O:26])[CH2:13]3)[CH2:19][CH2:18]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1