Pyrrolidine → N-{[1-(4-Phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2-pyrrolidin-1-yl-5-trifluoromethyl-benzamide

HRID 1893307Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1893307
F[C:2]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:3]=1[C:4]([NH:6][CH2:7][C:8](=[O:26])[NH:9][CH:10]1[CH2:13][N:12]([CH:14]2[CH2:19][CH2:18][CH:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:15]2)[CH2:11]1)=[O:5].[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[C:20]1([CH:17]2[CH2:16][CH2:15][CH:14]([N:12]3[CH2:11][CH:10]([NH:9][C:8]([CH2:7][NH:6][C:4](=[O:5])[C:3]4[CH:27]=[C:28]([C:31]([F:33])([F:34])[F:32])[CH:29]=[CH:30][C:2]=4[N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[O:26])[CH2:13]3)[CH2:19][CH2:18]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

3

Edukt 2

HCID 31268PyrrolidineHCID 497630992-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide

Produkt 1

HCID 49763226N-{[1-(4-Phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-2-pyrrolidin-1-yl-5-trifluoromethyl-benzamide

Versuchsvorschrift

The title compound was prepared as a white solid from coupling of 2-fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-5-trifluoromethyl-benzamide (as prepared in Example 66) and pyrrolidine (Aldrich) using the procedure described in Example 69.

Quellen und Nachweise

ORD-Eintrag
ord-b47ea647184b4e04a12cc2d69f538262
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08513229B2

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