Ethanolamine → 4-(2-Hydroxy-ethylamino)-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

HRID 1893311Notes

Reaction equation

HRID 1893311 reaction equation
F[C:2]1[CH:30]=[CH:29][C:5]([C:6]([NH:8][CH2:9][C:10](=[O:28])[NH:11][CH:12]2[CH2:15][N:14]([CH:16]3[CH2:21][CH2:20][CH:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH2:13]2)=[O:7])=[CH:4][C:3]=1[C:31]([F:34])([F:33])[F:32].[NH2:35][CH2:36][CH2:37][OH:38]>>[OH:38][CH2:37][CH2:36][NH:35][C:2]1[CH:30]=[CH:29][C:5]([C:6]([NH:8][CH2:9][C:10](=[O:28])[NH:11][CH:12]2[CH2:13][N:14]([CH:16]3[CH2:21][CH2:20][CH:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)[CH2:15]2)=[O:7])=[CH:4][C:3]=1[C:31]([F:34])([F:33])[F:32]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 497632274-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

Product 1

HCID 497633394-(2-Hydroxy-ethylamino)-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

Procedure

The title compound was prepared as a white solid from the coupling of 4-fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide (as prepared in Example 71) and 2-amino-ethanol (Aldrich) using the procedure described in Example 65.

Sources & evidence

ORD record
ord-cdad80112d8d432b949e2a01f6ae12a9
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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