HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 4-(2-Hydroxy-ethylamino)-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 4-Fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide | HCID 49763227 | — |
| Product | 4-(2-Hydroxy-ethylamino)-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide | HCID 49763339 | — |
Reaction Steps
The title compound was prepared as a white solid from the coupling of 4-fluoro-N-{[1-(4-phenyl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide (as prepared in Example 71) and 2-amino-ethanol (Aldrich) using the procedure described in Example 65.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513229B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-cdad80112d8d432b949e2a01f6ae12a9 |
| Source note | uspto-grants-2013_08 |