Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1893313Generated: October 29, 2026

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 59361639, compound

https://huagongshe.com/reaction/1893313

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
ReactantTert-butyl 3-aminoazetidine-1-carboxylateHCID 1516507—
ReactantGlycine, N-[3,5-bis(trifluoromethyl)benzoyl]-HCID 2797421—
ProductHCID 59361639HCID 59361639—

Reaction Steps

The title compounds were prepared as white solids from the EDCI coupling between 3-amino-azetidine-1-carboxylic acid tert-butyl ester and (3,5-bistrifluoromethyl-benzoylamino)-acetic acid (analog synthesis by following the procedure on Organic Synthesis XII, 40-2, 1932) using the procedure described in Step F of Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08513229B2
Source datasetuspto-grants-2013_08
ORD IDord-9921227d1dc64dffb975c95b4693d22b
Source noteuspto-grants-2013_08