N-(1,4-dioxaspiro[4.5]dec-8-ylidene)-2-methylpropane-2-sulfinamide → HCID 20453324, compound

HRID 1893330Notes

Reaction equation

HRID 1893330 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([Mg]Br)[CH:6]=[CH:7][CH:8]=1.[O:11]1[C:15]2([CH2:20][CH2:19][C:18](=[N:21]S(C(C)(C)C)=O)[CH2:17][CH2:16]2)OCC1>>[NH2:21][C:18]1([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:19][CH2:20][C:15](=[O:11])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 59733754N-(1,4-dioxaspiro[4.5]dec-8-ylidene)-2-methylpropane-2-sulfinamideHCID 178490745HCID 178490745, compound

Product 1

HCID 20453324HCID 20453324, compound

Procedure

The title compound was prepared as a white solid from addition of 3-methoxy-phenyl magnesium bromide (Aldrich) to 2-methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide (as prepared in Example 84, Step A) followed by hydrolysis using the procedure described in Step B of Example 84.

Workup

  1. customfollowed by hydrolysis

Sources & evidence

ORD record
ord-2ad7bfd22f71430eba26489a07483e5b
Source dataset
uspto-grants-2013_08
Patent number
US08513229B2

Reaction notes

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