1,1-Dimethoxyethyl(dimethyl)amine → HCID 178501169, compound

HRID 1893340Notes

Reaction equation

HRID 1893340 reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11](=[S:13])[NH2:12])[CH2:7][CH2:6]1)=[O:4].CO[C:16](OC)([N:18]([CH3:20])[CH3:19])[CH3:17]>>[CH3:1][O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11](=[S:13])[N:12]=[C:16]([N:18]([CH3:20])[CH3:19])[CH3:17])[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 178501132HCID 178501132, compound

Product 1

HCID 178501169HCID 178501169, compoundYield 93%

Procedure

A mixture of trans-4-thiocarbamoyl-cyclohexanecarboxylic acid methyl ester (0.72 g, 3.6 mmol) and N,N-dimethylacetamide dimethyl acetal (0.95 g, 7.2 mmol) was stirred at room temperature over night. The solvent was evaporated. Flash-chromatography with n-heptane/ethyl acetate as eluent gave the title compound (0.90 g, 93%) as yellow oil. MS m/e: 271 ([M+H]+)

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-139b2fa36bfd49e7a555d2dc3af945de
Source dataset
uspto-grants-2013_08
Patent number
US08513238B2

Reaction notes

Loading…