Hydrochloric Acid → HCID 178472455, compound

HRID 1893343Notes

Reaction equation

HRID 1893343 reaction equation
[CH2:1]([O:3][C:4]([C@H:6]1[CH2:11][CH2:10][C@@H:9]([NH:12][NH:13]C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].O1CCOCC1.[ClH:27]>>[ClH:27].[CH2:1]([O:3][C:4]([C@H:6]1[CH2:11][CH2:10][C@@H:9]([NH:12][NH2:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178472457HCID 178472457, compound

Product 1

HCID 178472455HCID 178472455, compound

Procedure

A solution of cis-4-(N′-tert-butoxycarbonyl-hydrazino)-cyclohexanecarboxylic acid ethyl ester (1.03 g, 3.60 mmol) in 4 M hydrogen chloride solution in 1,4-dioxane (9.0 ml, 36 mmol) was stirred at room temperature for 3 days. The precipitate was collected by filtration, washed with tert-butyl methyl ether and dried in vacuo to give the title compound as white solid in quantitative yield. MS m/e: 187 ([M+H]+).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with tert-butyl methyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7d43bf953c8445fe930f240b0bb1fe04
Source dataset
uspto-grants-2013_08
Patent number
US08513238B2

Reaction notes

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