Hydrochloric Acid → HCID 58367796, compound

HRID 1893388Notes

Reaction equation

HRID 1893388 reaction equation
Cl.CO[CH:4]([O:21]C)[CH2:5][NH:6][C:7]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][CH:12]=2)=[O:8]>CC(C)=O>[OH:21][CH:4]1[N:10]2[C:11]3[CH:12]=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][C:16]=3[CH:17]=[C:9]2[C:7](=[O:8])[NH:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68023578HCID 68023578, compound

Product 1

HCID 58367796HCID 58367796, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

HCl 2N (13.75 ml, 27.5 mmol, 2.5 eq.) was added to a solution of the compound of formula (IV) (3 g, 11 mmol, 1 eq.) in acetone (200 ml), the final solution was stirred at 25° C. for 48 h. The solution was dried under reduced pressure affording the compound of formula (V) as yellow solid that was used in the subsequent step without further purification. Same procedure on 30 g scale proceeded smoothly. Typical yield: 97%.

Workup

  1. customThe solution was dried under reduced pressure

Sources & evidence

ORD record
ord-512eaa4d7f354bedbbbb0b75f4edb807
Source dataset
uspto-grants-2013_08
Patent number
US08513241B2

Reaction notes

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