2,6-Dimethylcyclohexan-1-amine hydrochloride → 4-((R)-Tetrahydrofuran-3-yloxy)-5-bromo-N-(2,6-dimethylcyclohexyl)pyrimidin-2-amine

HRID 1893394Notes

Reaction equation

HRID 1893394 reaction equation
[Br:1][C:2]1[C:3]([O:9][C@@H:10]2[CH2:14][CH2:13][O:12][CH2:11]2)=[N:4][C:5](Cl)=[N:6][CH:7]=1.Cl.[CH3:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH:19]([CH3:23])[CH:18]1[NH2:24]>>[O:12]1[CH2:13][CH2:14][C@@H:10]([O:9][C:3]2[C:2]([Br:1])=[CH:7][N:6]=[C:5]([NH:24][CH:18]3[CH:19]([CH3:23])[CH2:20][CH2:21][CH2:22][CH:17]3[CH3:16])[N:4]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 222509422,6-Dimethylcyclohexan-1-amine hydrochlorideHCID 58515275HCID 58515275, compound

Product 1

HCID 585152574-((R)-Tetrahydrofuran-3-yloxy)-5-bromo-N-(2,6-dimethylcyclohexyl)pyrimidin-2-amine

Procedure

Using the procedure of Example 78, Step 2, (R)-5-bromo-2-chloro-4-(tetrahydrofuran-3-yloxy)pyrimidine was reacted with 2,6-dimethylcyclohexanamine HCl salt to provide the title compound. MS (ESI) m/z: Found: 370 (M++1), Calc. 369 (M+).

Sources & evidence

ORD record
ord-594c8da49fc24cee9c0e339c76b48ab9
Source dataset
uspto-grants-2013_08
Patent number
US08513242B2

Reaction notes

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