HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethylcyclohexan-1-amine hydrochloride → 4-((R)-Tetrahydrofuran-3-yloxy)-5-bromo-N-(2,6-dimethylcyclohexyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethylcyclohexan-1-amine hydrochloride | HCID 22250942 | — |
| Reactant | HCID 58515275 | HCID 58515275 | — |
| Product | 4-((R)-Tetrahydrofuran-3-yloxy)-5-bromo-N-(2,6-dimethylcyclohexyl)pyrimidin-2-amine | HCID 58515257 | — |
Reaction Steps
Using the procedure of Example 78, Step 2, (R)-5-bromo-2-chloro-4-(tetrahydrofuran-3-yloxy)pyrimidine was reacted with 2,6-dimethylcyclohexanamine HCl salt to provide the title compound. MS (ESI) m/z: Found: 370 (M++1), Calc. 369 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08513242B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-594c8da49fc24cee9c0e339c76b48ab9 |
| Source note | uspto-grants-2013_08 |