3-Phenylimidazo[1,2-a]pyrazine → 3-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

HRID 1893401Notes

Reaction equation

HRID 1893401 reaction equation
[C:1]1([C:7]2[N:11]3[CH:12]=[CH:13][N:14]=[CH:15][C:10]3=[N:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.[H][H].[Pt](=O)=O>[C:1]1([C:7]2[N:11]3[CH2:12][CH2:13][NH:14][CH2:15][C:10]3=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 1

HCID 208103403-Phenylimidazo[1,2-a]pyrazine

Product 1

HCID 248204983-Phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazineYield 99.3%

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 702EthanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

3-Phenylimidazo[1,2-a]pyrazine (1.391 g, 7.13 mmol) was dissolved in ethanol (100 ml) and hydrogenated at room temperature under 1 Atm hydrogen over platinum(IV) oxide (0.202 g, 0.713 mmol) for 24 hours. The catalyst was filtered, washed with ethanol and the filtrate concentrated to afford 3-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (1.41 g, 7.08 mmol, 99% yield)

Workup

  1. filtrationThe catalyst was filtered
  2. washwashed with ethanol
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-d2ae4614f0f74506939572360d6e6524
Source dataset
uspto-grants-2013_08
Patent number
US08513248B2

Reaction notes

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