Chlorosuccinimide → HCID 68007751, compound

HRID 1893412Notes

Reaction equation

HRID 1893412 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][C:5]=12.C1C(=O)N([Cl:24])C(=O)C1>C1(C)C=CC=CC=1>[Cl:24][C:3]1[N:4]2[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][C:5]2=[N:1][CH:2]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 21955306tert-Butyl 5,6-dihydroimidazo(1,2-a)pyrazine-7(8H)-carboxylate

Product 1

HCID 68007751HCID 68007751, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1,1-Dimethylethyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (I18) (1.563 g, 7 mmol) and NCS (0.935 g, 7.00 mmol) were heated at 80° C. for 2 h in toluene (30 mL). The solvents were removed in vacuo and the residue was purified by flash chromatography (Isolera, 50 g, 0-100% ethyl acetate/iso-hexane) to afford product in 1.55 g.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe residue was purified by flash chromatography (Isolera, 50 g, 0-100% ethyl acetate/iso-hexane)
  3. customto afford product in 1.55 g

Sources & evidence

ORD record
ord-edbae188d7a2426aa18db82a945e9468
Source dataset
uspto-grants-2013_08
Patent number
US08513248B2

Reaction notes

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