反应详情

1,1-Dimethylethyl 3-chloro-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (I19) (1.55 g, 6.01 mmol) and 4N HCl in 1,4-dioxane (6.01 mmol) was stirred at RT in 1,4-dioxane (5 mL) for 16 h. Solvents were removed in vacuo and the residue was loaded on to SCX (Varian 2×10 g) in methanol. The columns were washed with methanol and basic products eluted with 2M ammonia/methanol. The basic fractions were concentrated in vacuo to afford product in 913 mg that was used in subsequent steps without further purification.

1. customSolvents were removed in vacuo
2. washThe columns were washed with methanol and basic products
3. washeluted with 2M ammonia/methanol
4. concentrationThe basic fractions were concentrated in vacuo
5. customto afford product in 913 mg that
6. customwas used in subsequent steps without further purification