Lithium Hydroxide → HCID 178524133, compound

Participants

Reaction Steps

A solution of 5-[4-(3-Hydroxy-propylamino)-7-trifluoromethyl-imidazo[1,2-a]quinoxalin-1-yl]-1H-pyrazole-3-carboxylic acid ethyl ester (0.12 mmol; 54 mg), LiOH (0.13 mmol; 3 mg), in THF/H2O (0.2+0.1 mL), was stirred at 40° C. overnight. Further LiOH (0.26 mmol; 6 mg) was added, and the reaction was continued at 50° C. another 24 hr. Concentration, and washing with water affords the title compound, as a white solid, lithium salt (51 mg; 0.12 mmol; 100%).

Provenance & Evidence