Lithium Hydroxide → HCID 178524133, compound

HRID 1893469Notes

Reaction equation

HRID 1893469 reaction equation
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[N:15]3[C:16]4[C:21]([N:22]=[C:23]([NH:24][CH2:25][CH2:26][CH2:27][OH:28])[C:14]3=[N:13][CH:12]=2)=[CH:20][C:19]([C:29]([F:32])([F:31])[F:30])=[CH:18][CH:17]=4)[NH:8][N:7]=1)=[O:5])C.[Li+].[OH-]>C1COCC1.O>[OH:28][CH2:27][CH2:26][CH2:25][NH:24][C:23]1[C:14]2[N:15]([C:11]([C:9]3[NH:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=3)=[CH:12][N:13]=2)[C:16]2[C:21]([N:22]=1)=[CH:20][C:19]([C:29]([F:31])([F:30])[F:32])=[CH:18][CH:17]=2

Participants

4

Reactant 2

HCID 3939Lithium Hydroxide2×HCID 178468649HCID 178468649, compound

Product 1

HCID 178524133HCID 178524133, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A solution of 5-[4-(3-Hydroxy-propylamino)-7-trifluoromethyl-imidazo[1,2-a]quinoxalin-1-yl]-1H-pyrazole-3-carboxylic acid ethyl ester (0.12 mmol; 54 mg), LiOH (0.13 mmol; 3 mg), in THF/H2O (0.2+0.1 mL), was stirred at 40° C. overnight. Further LiOH (0.26 mmol; 6 mg) was added, and the reaction was continued at 50° C. another 24 hr. Concentration, and washing with water affords the title compound, as a white solid, lithium salt (51 mg; 0.12 mmol; 100%).

Workup

  1. concentrationConcentration
  2. washwashing with water

Sources & evidence

ORD record
ord-c4b3d5efd2c843a58e8165f9f7d696bd
Source dataset
uspto-grants-2013_08
Patent number
US08513250B2

Reaction notes

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