Hydrogen chloride-ethyl acetate → HCID 86650774, compound

HRID 1893505Notes

Reaction equation

HRID 1893505 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([N:5]([CH2:16][C:17]([F:20])([F:19])[F:18])[CH2:6][CH2:7][NH:8]C(=O)OC(C)(C)C)=[O:4].[ClH:23].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:23].[NH2:8][CH2:7][CH2:6][N:5]([CH2:16][C:17]([F:18])([F:19])[F:20])[C:3](=[O:4])[C:2]([F:22])([F:1])[F:21]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 866507751,1-Dimethylethyl N-[2-[(2,2,2-trifluoroacetyl)(2,2,2-trifluoroethyl)amino]ethyl]carbamate

Product 1

HCID 86650774HCID 86650774, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The compound (3.05 g, 9.02 mmol) obtained in step C was dissolved in ethyl acetate (20 ml), 4N hydrochloric acid-ethyl acetate solution (10 ml) was added, and the mixture was stirred at room temperature for 6 hr. The precipitated solid was collected by filtration, and the obtained solid was washed with ethyl acetate, and dried under reduced pressure to give the title compound (1.51 g, yield 61%) as a pale-bistered solid.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washthe obtained solid was washed with ethyl acetate
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-68d0baac8a7f4448b6f87a0db761b7c9
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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