2-nitroso-1,2,3,4-tetrahydroisoquinoline → N-methyl-3,4-dihydro-1H-isoquinolin-2-amine

HRID 1893518Notes

Reaction equation

HRID 1893518 reaction equation
[CH2:1]=[N:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.N(N1CCC2C(=CC=CC=2)C1)=O>>[CH3:1][NH:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1

Participants

3

Reactant 2

HCID 122768662-nitroso-1,2,3,4-tetrahydroisoquinolineHCID 66881110HCID 66881110, compound

Product 1

HCID 409505N-methyl-3,4-dihydro-1H-isoquinolin-2-amineYield 95%

Procedure

Using N-methylene-3,4-dihydroisoquinolin-2 (1H)-amine and the compound (3.00 g, 18.5 mmol) obtained in step A, and according to the method of Reference Example 37, step B, the title compound (2.86 g, yield 95%) was obtained as a pale-yellow oil.

Sources & evidence

ORD record
ord-6058bc7855034e9f8089b71b0a4a8537
Source dataset
uspto-grants-2013_08
Patent number
US08513235B2

Reaction notes

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