2-nitroso-1,2,3,4-tetrahydroisoquinoline → N-methyl-3,4-dihydro-1H-isoquinolin-2-amine

Participants

Role	Name	HCID	Charge
Reactant	2-nitroso-1,2,3,4-tetrahydroisoquinoline	HCID 12276866	—
Reactant	HCID 66881110	HCID 66881110	—
Product	N-methyl-3,4-dihydro-1H-isoquinolin-2-amine	HCID 409505	95%

Reaction Steps

Using N-methylene-3,4-dihydroisoquinolin-2 (1H)-amine and the compound (3.00 g, 18.5 mmol) obtained in step A, and according to the method of Reference Example 37, step B, the title compound (2.86 g, yield 95%) was obtained as a pale-yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513235B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-6058bc7855034e9f8089b71b0a4a8537
Source note	uspto-grants-2013_08